DHODH Inhibitors Based on the Vidofludimus Scaffold Containing Carboxylic Acid Bioisosteres Exert a Superior Broad-Spectrum Antiviral Activity

Alexandra Herrmann, Friedrich Hahn, Christina Wangen, Sabrina Wagner, Arne Cordsmeier, Pascal Irrgang, Tatjana Weil, Victoria Hunszinger, Rüdiger Groß, Natalie Heinen, Stephanie Pfaender, Saskia Westhoven, Sebastian Reuter, Michaela Schedel, Nadja Uhlig, Valentina Eberlein, Leila Issmail, Thomas Grunwald, Robert Klopfleisch, Armin Ensser, Matthias Tenbusch, Jan Münch, Konstantin M. J. Sparrer, Manfred Marschall, Hella Kohlhof, Daniel Vitt, Christian Gege

Journal of Medicinal Chemistry
Published: June 3, 2026

https://doi.org/10.1021/acs.jmedchem.5c03715